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	Long Term Follow Up of Survivors of a Malignant Bone Tumor Authors: C. A. J. Brouwer, J. A. Gietema, M. P. van den Berg, M. T. E. Bink-Boelkens, N. J. Elzenga, J. Haaksma, W. A. Kamps, J. M. Vonk, E. G. E. de Vries & A. Postma Late Effects (Malignant Bone Tumor) Journal Details Annals of Oncology, July 20, 2006 Longitudinal studies of cardiac function in long-term childhood cancer survivors are scarce and frequently concern a median follow-up shorter than 13 years. Twenty-two years after doxorubicin-treatment, bone tumour survivors showed progressive cardiac dysfunction. Download article as PDF (You will need Adobe Acrobat Reader in order to view this document.)
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	The Two-Edged Sword of Curing Childhood Cancer Author: Philip M. Rosoff, MD Late Effects (General) Journal Details New England Journal of Medicine, Oct. 12, 2006, Vol. 355, No. 15, pp. 1522-1523 Read Complete Article Here In this short essay, Dr. Rosoff discusses the fact that the victories of curing so many children diagnosed with cancer is not without its difficulties, with a large number of these children growing up to be adults with late effects of treatment. Dr. Rosoff writes that “it is clear that the effects of childhood cancer – like those of sickle cell anemia, cystic fibrosis, and many other diseases that begin in childhood – do not end when the patient reaches the magic age of 18 or 21 years. Although the child with cancer may be cured, the effects of treatment are lifelong, and we need to study and treat these late effects.”




	Chronic Health Conditions in Adult Survivors of Childhood Cancer Author: Kevin C. Oeffinger, MD, et al Late Effects (General) Journal Details JAMA, April 10, 2002, Vol. 287, No. 14; pp. 1832-1839 Read Complete Article Here This article made a very important point about the difficulty that nearly all childhood cancer survivors have in accurately remembering their past cancer diagnosis and the specifics of the treatment. In fact, the study found that not one survivor could provide an accurate, detailed summary of their medical history including type of cancer, drugs administered, or exact site of radiation therapy. The article concluded that "important knowledge deficits exist among adult survivors of childhood cancer regarding basic aspects of their diagnosis and treatment. Such deficits could impair survivors' ability to seek and receive appropriate long-term follow-up care."



	Childhood Cancer Survivors' Knowledge About Their Past Diagnosis and Treatment: Childhood Cancer Survivor Study Author: Nancy S. Kadan-Lottick, MD, et al Late Effects (General) Journal Details JAMA, April 10, 2002, Vol. 287, No. 14; pp. 1832-1839 This article made a very important point about the difficulty that nearly all childhood cancer survivors have in accurately remembering their past cancer diagnosis and the specifics of the treatment. In fact, the study found that not one survivor could provide an accurate, detailed summary of their medical history including type of cancer, drugs administered, or exact site of radiation therapy. The article concluded that "important knowledge deficits exist among adult survivors of childhood cancer regarding basic aspects of their diagnosis and treatment. Such deficits could impair survivors' ability to seek and receive appropriate long-term follow-up care."



	State of the Science on Nursing Approaches to Managing Late and Long-Term Sequelae of Cancer and Cancer Treatment Multiple authors Editors: Carol P. Curtiss, MSN, RN-C Pamela J. Haylock, MA, RN Late Effects (General) Journal Details New England Journal of Medicine, Oct. 12, 2006, Vol. 355, No. 15, pp. 1572-1582 This article determines the incidence and severity of health conditions in adult survivors of childhood cancer and finds that these individuals have a high rate of illness due to chronic health conditions. The authors note that “adult survivors of pediatric cancer who were treated in the 1970’s and 1980’s are a high risk population. Thirty years after a diagnosis of cancer, almost three fourths of survivors have a chronic health condition, more than 40% have a serious health program, and one third have multiple conditions. The incidence of health conditions reported by the population increases with time and does not appear to plateau. The monitoring of survivors is an important part of their overall health care.”



	Double Jeopardy Author: Paroma Basu Late Effects (General) Journal Details Nature Medicine, Vol. 11, Number 11, Pages 1132-1133, November 2005, at a meeting of the American Society of Clinical Oncology in May. Effective new treatments have saved millions of children from the clutches of cancer. But in this article, Paroma Basu discovers that those miracle cures may keep them sick for the rest of their lives. Two of the founding members of this website were highlighted in this excellent article about late effects of cancer treatments.



	Health Issues in Survivors of Childhood Cancer Author: Sharon Castellino, MD, Melissa M. Hudson, MD Late Effects (General) Journal Details South Med J., 95(9): 977-984, 2002 Southern Medical Association This article explores the range of late effects that childhood cancer survivors are at risk for, and point out the need for life long monitoring. This article has good detail and includes follow-up guidelines. However more recent and detailed guidelines have been published by the Children's Oncology Group and these should be used instead in consultation with your doctor.



	Health Status of Adult Long-Term Survivors of Childhood Cancer-A Report from the Childhood Cancer Survivor Study Author: Melissa M. Hudson, MD, et al Late Effects (General) Journal Details JAMA, September 24, 2003, Vol. 290, No. 12, pp 1583-1592 This article explores the risks for medical and psychosocial late effects that adversely affect the health status of many childhood cancer survivors. The goal of the study was to describe the health status of adult long-term survivors of childhood cancer and to 1) determine the prevalence of adverse health status, 2) compare the health status of survivors with siblings, and 3) identify factors associated with adverse health status in survivors.



	Late Mortality Experience in Five-Year Survivors of Childhood and Adolescent Cancer: The Childhood Cancer Survivor Study Author: Ann C. Mertens, et al Late Effects (General) Journal Details Journal of Clinical Oncology, Vol. 19, No. 13, (July 1), 2001, pp. 3163-3172 This article is based on the results of the Childhood Cancer Survivor Study and focuses on, for those that had passed away after five years following treatment, the underlying cause for death. The findings showed a 10.8-fold increase in overall mortality. This article shows that risks in the years after completion of cancer treatment are significant and can lead to death. This article underscores the need for close monitoring for late-effects.



	The cancer screening practices of adult survivors of childhood cancer - A report from the Childhood Cancer Survivor Study Author: Mark W. Yeazel, Kevin C. Oeffinger, James G. Gurney, Ann C. Mertens, Melissa M. Hudson, Karen M. Emmons, egang Chen, Leslie L. Robison, Late Effects (General) Journal Details Cancer, Published online 12/15/03 in advance of print. A report from the Childhood Cancer Survivor Study. The results of the current study demonstrate that the cancer screening practices among survivors of childhood cancer are below optimal levels. Primary care physicians who include childhood cancer survivors among their patients could benefit these individuals by informing them about future cancer risks and recommending appropriate evidence-based screening.



	Health Care of Young Adult Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study Author: Kevin C. Oeffinger, Ann C. Mertens, Melissa M. Hudson, James G. Gurney, Jacqueline Casillas, Hegang Chen, John Whitton, Mark Yeazel, Yutaka Yasui, and Leslie L. Robison Late Effects (General) Journal Details Ann Fam Med 2004; 2: 61-70 Concludes that primary care physicians provide health care for most of this growing high-risk population. To optimize risk-based care, it is critical that cancer centers and primary care physicians develop methods to communicate effectively and longitudinally.

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